Ready-to-Mix Transparent Emulsions, Extremely Safe, Flexible Ratio with Aqueous Antigen, Hardly Interfered by Surfactant-Like Immunostimulants, Perfect Base for Cationic NanoEmulsion
40nm (10-300 Range) Clear Liquid Formulation
Mineral Oil Based for Veterinary Vaccines and Squalene Based for Human Vaccines
Supplied as Oil Phase – SDA 7749
Advantageous for human and those animal species with safety as concern. Induce rapid immune response. SDA7749 is ready-to-dilute adjuvant containing a mixture of micro-emulsions and an immunostimulant compound. They can be used with several antigens — bacterial, viral, parasitic or subunit
Generate by mixing with PBS the clear type diluent for MLV antigens, and for spray or immerse immunizations.
Some vaccine manufacturers mix adjuvant with antigens and filter the end products
Some vaccine manufacturers pasteurize bulk adjuvant and cool re-homogenize prior to mix with antigens.
Mechanical stirring process is recommended. Most customers use speed of 60-120 rpm for tank mixing.
Vaccine formulations can be obtained by an easy dilution of the aqueous medium into microemulsion, at room temperature or less, under gentle agitation (e.g. marine propeller, magnetic stirrer).
Alternatively, SDA 7749 adjuvants can be emulsified in the presence of an aqueous medium or PBS. The end users combine the transparent microemulsion with antigen according to a dedicated manufacturing process.
The fatty phase can consist of an oil from a mineral (Drakeol 6VR), vegetable derived squalene, or synthetic origin, or of a combination of these different oils. The surfactant is synthesized and selected for each adjuvant by optimizing its hydrophilic-lipophilic balance, depending on the type of emulsion sought and the fatty phase selected.